[钙拮抗剂地尔硫䓬对缺血性心脏病患者血浆中前列环素 - 血栓素比例的影响]
[Effect of the calcium antagonist diltiazem on the prostacyclin-thromboxane ratio in the plasma of ischemic heart disease patients].
作者信息
Brovkovich V M, Topchiĭ I I, Abidov A A
出版信息
Vopr Med Khim. 1991 Mar-Apr;37(2):37-9.
PMID:1897189
Abstract
Content of prostacyclin and thromboxane was studied in blood plasma of patients with ischemic heart disease after single administration of calcium antagonist diltiazem. The drug caused an increase in content of prostacyclin and in the ratio prostacyclin/thromboxane. Diltiazem appears to differently affect the arachidonic acid metabolism in platelets and endothelial cells that may be involved in therapeutic effect of the drug under conditions of ischemic heart disease.
摘要
在缺血性心脏病患者单次服用钙拮抗剂地尔硫䓬后，对其血浆中前列环素和血栓素的含量进行了研究。该药物导致前列环素含量及前列环素/血栓素比值增加。地尔硫䓬似乎对血小板和内皮细胞中的花生四烯酸代谢有不同影响，这可能与该药物在缺血性心脏病情况下的治疗作用有关。
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