Volkov V I, Ladnyĭ A I
Vrach Delo. 1989 Nov(11):60-2.
Results of treatment of patients with stable stenocardia by means of nitrates indicate that the antianginal effect was parallelled by an increase of the sensitivity of thrombocytes to prostacyclin and level of the plasma metabolite prostacyclin. The hypolipidemic effect of miscleron therapy is accompanied in patients with ischemic heart disease by reduction of the aggregation properties of thrombocytes and level of the metabolite thromboxane A2 in the plasma. The rationality of combined treatment with miscleron and nitrates is substantiated from the position of aimed effect on important links of atherogenesis and ischemic heart disease, namely functional properties of thrombocytes, prostacyclin-thromboxane ratio and level of blood lipids.
用硝酸盐类药物治疗稳定型心绞痛患者的结果表明，抗心绞痛作用伴随着血小板对前列环素敏感性的增加以及血浆代谢产物前列环素水平的升高。在缺血性心脏病患者中，米斯克隆疗法的降血脂作用伴随着血小板聚集特性的降低以及血浆中代谢产物血栓素A2水平的降低。从对动脉粥样硬化和缺血性心脏病的重要环节，即血小板的功能特性、前列环素-血栓素比值和血脂水平的靶向作用来看，米斯克隆与硝酸盐类药物联合治疗的合理性得到了证实。
