Kniazewska Maria H, Obuchowicz Anna K, Wielkoszyński Tomasz, Zmudzińska-Kitczak Joanna, Urban Katarzyna, Marek Marta, Witanowska Jolanta, Sieroń-Stołtny Karolina
Department of Pediatrics in Bytom, Medical University of Silesia, Katowice, Poland.
Pediatr Nephrol. 2009 Mar;24(3):549-54. doi: 10.1007/s00467-008-1029-1. Epub 2008 Oct 30.
A total of 30 patients (ten female/20 male), 9 years to 22 years old (mean age 17.3 years) and 30 healthy teenage controls (mean age 16.4 years) were included in our study. The patients had steroid-sensitive idiopathic nephrotic syndrome (INS) and had completed steroid therapy 4 years to 15 years ago. Height and weight, body mass index (BMI), body composition, and intima-media thickness (IMT) were determined, as were levels of total cholesterol (TCh), low-density lipoprotein cholesterol (LDL-Ch), high-density lipoprotein cholesterol (HDL-Ch), triacylglycerols (TAGs), homocysteine (HCY), and high-sensitivity C-reactive protein (hsCRP). We did not observe any differences between the study and control groups in IMT (0.47 +/- 0.1 vs 0.46 +/- 0.1 mm) and body composition (fat tissue and water content). Differences in HDL-Ch and hsCRP levels between groups were not significant. In the study group we found significantly higher TCh levels (187.6 +/- 57.2 mg/dl vs 158.8 +/- 25.7 mg/dl; P = 0.012), LDL-Ch (115.9 +/- 63.7 mg/dl vs 79.4 +/- 25.4 mg/dl; P = 0.005), HCY (12.3 +/- 7.7 micromol/l vs 7.6 +/- 1.6 micromol/dl; P < 0.001), apolipoprotein B (ApoB) (113.6 +/- 30.0 mg/dl vs 78.7 +/- 13.6 mg/dl; P < 0.001) and ApoA1 (203.5 +/- 50.8 mg/dl vs 156.5 +/- 12.4 mg/dl; P < 0.001) levels. Multi-factor analysis of the influence of independent factors (number of recurrences, duration of remission, age, gender, and BMI) on the parameters under investigation indicated a positive correlation between IMT and the number of recurrences.
本研究纳入了30例患者（10例女性/20例男性），年龄在9岁至22岁之间（平均年龄17.3岁），以及30名健康青少年对照者（平均年龄16.4岁）。这些患者患有类固醇敏感型特发性肾病综合征（INS），并在4年至15年前完成了类固醇治疗。测定了身高、体重、体重指数（BMI）、身体成分和内膜中层厚度（IMT），以及总胆固醇（TCh）、低密度脂蛋白胆固醇（LDL-Ch）、高密度脂蛋白胆固醇（HDL-Ch）、甘油三酯（TAGs）、同型半胱氨酸（HCY）和高敏C反应蛋白（hsCRP）水平。我们未观察到研究组与对照组在IMT（0.47±0.1对0.46±0.1毫米）和身体成分（脂肪组织和含水量）方面存在任何差异。两组之间HDL-Ch和hsCRP水平的差异不显著。在研究组中，我们发现TCh水平（187.6±57.2毫克/分升对158.8±25.7毫克/分升；P = 0.012）、LDL-Ch（115.9±63.7毫克/分升对79.4±25.4毫克/分升；P = 0.005）、HCY（12.3±7.7微摩尔/升对7.6±1.6微摩尔/分升；P < 0.001）、载脂蛋白B（ApoB）（113.6±30.0毫克/分升对78.7±13.6毫克/分升；P < 0.001）和ApoA1（203.5±50.8毫克/分升对156.5±12.4毫克/分升；P < 0.001）显著更高。对独立因素（复发次数、缓解期持续时间、年龄、性别和BMI）对所研究参数影响的多因素分析表明，IMT与复发次数之间存在正相关。
