Luo Nan, Tan Louis C S, Zhao Yingjiao, Lau Puay-Ngoh, Au Wing-Lok, Li Shu Chuen
Department of Community, Occupational and Family Medicine and Centre for Health Services Research, National University of Singapore, Republic of Singapore.
Mov Disord. 2009 Jan 30;24(2):183-7. doi: 10.1002/mds.22240.
The aim of our study was to assess the longitudinal validity of the 8-item Parkinson's Disease Questionnaire (PDQ-8) in terms of responsiveness and test-retest reliability and to determine the minimally important difference (MID) for PDQ-8 using the anchor-based approach in Asians with Parkinson's disease (PD). A consecutive sample of PD patients attending a tertiary neuroscience clinic in Singapore completed the English or Chinese version of PDQ-8 twice during two different clinic visits. During the second visit, patients were also asked to rate their changes in health in general, PD severity, and overall impact of PD since at the time of their first visit 1 year ago using a 5-point response scale. A total of 96 patients participated in the study. For patients who reported changed conditions in the second visit, responsiveness measured by Cohen's effect size, standardized response mean, and Guyatt's responsiveness index ranged from 0.21 to 0.68. The intraclass correlation coefficient values calculated using patients reporting no change in health or PD status ranged from 0.64 to 0.76. The mean changed PDQ-8 summary index score in patients who reported that their health or PD status worsened only "a little bit" ranged from 5.8 to 7.4 points. Our current results show that PDQ-8 is a longitudinally reliable and responsive measure for assessing the health-related quality of life in patients with PD. The MID of the PDQ-8 estimated in the study will further support the use of this instrument in both clinical research and practice.
我们研究的目的是评估8项帕金森病问卷（PDQ - 8）在反应性和重测信度方面的纵向效度，并采用基于锚定法确定亚洲帕金森病（PD）患者中PDQ - 8的最小重要差异（MID）。在新加坡一家三级神经科学诊所就诊的连续样本的PD患者在两次不同的门诊就诊期间完成了英文或中文版的PDQ - 8。在第二次就诊时，还要求患者使用5分制反应量表对自1年前首次就诊以来其总体健康变化、PD严重程度和PD的总体影响进行评分。共有96名患者参与了该研究。对于在第二次就诊时报告病情有变化的患者，用科恩效应量、标准化反应均值和盖亚特反应性指数衡量的反应性范围为0.21至0.68。使用报告健康或PD状态无变化的患者计算的组内相关系数值范围为0.64至0.76。报告健康或PD状态仅“稍有”恶化的患者中，PDQ - 8总结指数得分的平均变化范围为5.8至7.4分。我们目前的结果表明，PDQ - 8是评估PD患者健康相关生活质量的纵向可靠且有反应性的指标。该研究中估计的PDQ - 8的MID将进一步支持该工具在临床研究和实践中的应用。
