Zhang Jia-Jia, Dai Jing-Bo, Chen Li-Li, Ding Ping-Yue, Wu Jun
Zhejiang Pharmaceutical College, Ningbo 315200, China.
Zhong Yao Cai. 2008 Jul;31(7):1001-3.
To study the bioactive triterpene glycosides from sea cucumber Holothuria nobilis.
Guided by Pyricularia oryzae bioassay method, the glycosides compounds were separated by multi-chromatography, and their structures were elucidated by chemical and spectral analysis.
Twelve triterpene glycosides were obtained and their structures were identified, including seven novel saponins. All saponins showed activities on P. oryzae, and most of them exhibited cytotoxicity on P388 and A549 significantly.
Our researches provided valuable leads for pursuing new anticancer drugs, and established a homebase for further development of H. nobilis which is widely distributed in South China Sea.
研究糙海参中的生物活性三萜糖苷。
以稻瘟病菌生物测定法为指导，通过多种色谱法分离糖苷化合物，并通过化学和光谱分析阐明其结构。
获得了12种三萜糖苷并鉴定了其结构，其中包括7种新型皂苷。所有皂苷均对稻瘟病菌有活性，且大多数对P388和A549表现出显著的细胞毒性。
我们的研究为寻找新的抗癌药物提供了有价值的线索，并为进一步开发广泛分布于中国南海的糙海参奠定了基础。
