一种来自糙海参的新型细胞毒性羊毛甾烷型三萜糖苷。

A new cytotoxic lanostane-type triterpene glycoside from the sea cucumber Holothuria impatiens.

作者信息

Sun Peng, Liu Bao-Shu, Yi Yang-Hua, Li Ling, Gui Min, Tang Hai-Feng, Zhang Da-Zhi, Zhang Shi-Long

机构信息

Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR. China.

出版信息

Chem Biodivers. 2007 Mar;4(3):450-7. doi: 10.1002/cbdv.200790037.

DOI:10.1002/cbdv.200790037

PMID:17372947

Abstract

A new lanostane-type triterpene glycoside, impatienside A (1), was isolated from the sea cucumber Holothuria impatiens, together with a structurally related, known compound, bivittoside D (2). Their structures were elucidated by in-depth spectroscopic and mass-spectrometric methods, including (1)H-, (13)C-, and 2D-NMR, ESI-MS, and HR-ESI-MS experiments, as well as by chemical evidence. Compounds 1 and 2 possess the same hexasaccharide moieties, but differ slightly in their holostane-type triterpene aglycone. The two glycosides were found to exhibit in vitro cytotoxicities similar to or better than those of the potent anticancer drug etoposide (V-16) against seven different human tumor cells, with IC50 values of 0.37-2.75 microg/ml.

摘要

从海参光参中分离出一种新的羊毛甾烷型三萜糖苷——凤仙皂苷A（1），以及一种结构相关的已知化合物——双 vittoside D（2）。通过深入的光谱和质谱方法，包括（1）H-、（13）C-和二维核磁共振、电喷雾电离质谱和高分辨电喷雾电离质谱实验，以及化学证据，阐明了它们的结构。化合物1和2具有相同的六糖部分，但在其羊毛甾烷型三萜苷元上略有不同。发现这两种糖苷对七种不同的人类肿瘤细胞表现出与强效抗癌药物依托泊苷（V-16）相似或更好的体外细胞毒性，IC50值为0.37 - 2.75微克/毫升。