Zhang Jia-Jia, Zhu Qi-Ke, Wu Jun, Zhang Hui-Wen
Nat Prod Commun. 2015 Feb;10(2):247-8.
A new cytotoxic triterpene glycoside named nobiliside E (1) has been obtained from the East China Sea cucumber Holothuria nobilis Selenka. Its structure was determined on the basis of NMR spectroscopic and MS analyses, together with chemical evidence. The new compound showed significant cytotoxicity to eight human tumor cell lines with IC50 values in the range of 0.53-4.06 μg/mL.
从中国东海海参黑乳海参（Holothuria nobilis Selenka）中获得了一种名为诺比利苷E（1）的新型细胞毒性三萜糖苷。其结构是基于核磁共振光谱和质谱分析以及化学证据确定的。该新化合物对八种人类肿瘤细胞系显示出显著的细胞毒性，IC50值在0.53-4.06μg/mL范围内。
