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从海参 Holothuria leucospilota 中分离得到的一种新型硫酸化甾烷糖苷。

A novel sulfated holostane glycoside from sea cucumber Holothuria leucospilota.

机构信息

Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guo-He Road, Shanghai 200433, P. R. China.

出版信息

Chem Biodivers. 2010 Jul;7(7):1764-9. doi: 10.1002/cbdv.200900094.

DOI:10.1002/cbdv.200900094
PMID:20658664
Abstract

A new sulfated holostane glycoside, leucospilotaside B (1), together with the two related structurally known compounds holothurin B(2) (2) and holothurin B (3), was isolated from sea cucumber Holothuria leucospilota collected from the South China Sea. The structure of 1 was elucidated by spectral analysis (1H-, 13C-, and 2D-NMR, ESI-MS, and HR-ESI-MS) and chemical methods. The compounds 1-3 possess the same disaccharide moiety, but were different in the side chains of the triterpene aglycone. Compound 1 showed significant cytotoxicities against four human tumor cell lines, HL-60, MOLT-4, A-549, and BEL-7402.

摘要

从南海采集的海参糙海参中分离得到一种新的硫酸甾烷糖苷，即亮海参苷 B（1），以及两种结构上相关的已知化合物海兔素 B（2）（2）和海兔素 B（3）。通过光谱分析（1H-、13C-和 2D-NMR、ESI-MS 和 HR-ESI-MS）和化学方法阐明了 1 的结构。化合物 1-3 具有相同的二糖部分，但三萜糖苷配基的侧链不同。化合物 1 对四种人肿瘤细胞系 HL-60、MOLT-4、A-549 和 BEL-7402 表现出显著的细胞毒性。

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