Helsel Amber Jade, Brown Amy L, Yamato Kazuhiro, Feng Wen, Yuan Lihua, Clements Aimee J, Harding Stephanie V, Szabo Gabor, Shao Zhifeng, Gong Bing
Department of Chemistry, Natural Sciences Complex, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.
J Am Chem Soc. 2008 Nov 26;130(47):15784-5. doi: 10.1021/ja807078y.
Oligoamide macrocycles 1d and 1e, which carry membrane-compatible side chains and contain a hydrophilic, noncollapsible cavity, were found to mediate high ion flux across a lipid bilayer, as demonstrated by results from (23)Na NMR and planar bilayer conductance measurements. The measured transmembrane single channel currents are very high, rivaling those typically associated with pore-forming protein toxins. The obtained results have demonstrated the promise of developing large, highly conducting channels based on nanopores formed by oligoamide macrocycles.
携带与膜兼容侧链且含有亲水性、不可塌陷腔的寡酰胺大环化合物1d和1e，经（23）Na NMR和平面双层电导测量结果表明，可介导高离子通量穿过脂质双层。测得的跨膜单通道电流非常高，可与通常与成孔蛋白毒素相关的电流相媲美。所得结果表明了基于寡酰胺大环化合物形成的纳米孔开发大型、高导电通道的前景。
