Hammarbäck S, Ekholm U B, Bäckström T
Department of Obstetrics and Gynecology, University of Umeå, Sweden.
Acta Endocrinol (Copenh). 1991 Aug;125(2):132-7. doi: 10.1530/acta.0.1250132.
In the premenstrual syndrome the negative symptoms appear during the luteal phase of the menstrual cycle. Ovulation and the formation of a corpus luteum seem to be of great importance in precipitating the syndrome. In a large group of women with premenstrual syndrome investigated daily with symptom ratings and weekly plasma estradiol and progesterone assays, 8 were found to have one ovulatory and one spontaneously occurring anovulatory menstrual cycle. In both these cycles, the post- and premenstrual phases were compared by testing for recurrence of symptoms. All patients showed a highly significant cyclical worsening of negative premenstrual symptoms during the ovulatory cycles, whereas in the anovulatory cycles the cyclical symptoms disappeared, resulting in relief of the premenstrual syndrome. These results support earlier hypotheses, suggesting that the premenstrual syndrome appears as a result of provoking factors produced by the corpus luteum. This view is in line with earlier therapeutic findings showing that induced anovulation can relieve the premenstrual syndrome.
在经前期综合征中，负面症状出现在月经周期的黄体期。排卵和黄体的形成似乎在引发该综合征方面极为重要。在一大组经前期综合征女性中，每天进行症状评分，并每周检测血浆雌二醇和孕酮，发现其中8人有一个排卵性月经周期和一个自然发生的无排卵性月经周期。在这两个周期中，通过检测症状复发情况对经后期和经前期进行了比较。所有患者在排卵周期中经前期负面症状出现高度显著的周期性加重，而在无排卵周期中，周期性症状消失，从而缓解了经前期综合征。这些结果支持了早期的假设，表明经前期综合征是由黄体产生的激发因素导致的。这一观点与早期的治疗结果一致，即诱导无排卵可缓解经前期综合征。
