关于《光和食物可调节昼夜节律的差异拯救》的评论
Comment on "Differential rescue of light- and food-entrainable circadian rhythms".
作者信息
Mistlberger Ralph E, Yamazaki Shin, Pendergast Julie S, Landry Glenn J, Takumi Toru, Nakamura Wataru
机构信息
Department of Psychology, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
出版信息
Science. 2008 Oct 31;322(5902):675; author reply 675. doi: 10.1126/science.1161387.
Abstract
Fuller et al. (Reports, 23 May 2008, p. 1074) reported that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food-entrained circadian rhythms. We report that mice bearing a null mutation of Bmal1 exhibit normal food-anticipatory circadian rhythms. Lack of food anticipation in Bmal1-/- mice reported by Fuller et al. may reflect morbidity due to weight loss, thus raising questions about their conclusions.
摘要
富勒等人（《报告》，2008年5月23日，第1074页）报告称，下丘脑背内侧包含一个基于Bmal1的振荡器，它可以驱动食物诱导的昼夜节律。我们报告称，携带Bmal1无效突变的小鼠表现出正常的食物预期昼夜节律。富勒等人报告的Bmal1基因敲除小鼠缺乏食物预期，可能反映了体重减轻导致的发病率，因此对他们的结论提出了质疑。
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