• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

腹内侧下丘脑的瘦素受体神经元输入到昼夜节律性摄食网络中。

Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network.

机构信息

Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.

Program in Fundamental Neuroscience, Charlottesville, VA 22904, USA.

出版信息

Sci Adv. 2023 Aug 25;9(34):eadh9570. doi: 10.1126/sciadv.adh9570.

DOI:10.1126/sciadv.adh9570
PMID:37624889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10456850/
Abstract

Salient cues, such as the rising sun or availability of food, entrain biological clocks for behavioral adaptation. The mechanisms underlying entrainment to food availability remain elusive. Using single-nucleus RNA sequencing during scheduled feeding, we identified a dorsomedial hypothalamus leptin receptor-expressing (DMH) neuron population that up-regulates circadian entrainment genes and exhibits calcium activity before an anticipated meal. Exogenous leptin, silencing, or chemogenetic stimulation of DMH neurons disrupts the development of molecular and behavioral food entrainment. Repetitive DMH neuron activation leads to the partitioning of a secondary bout of circadian locomotor activity that is in phase with the stimulation and dependent on an intact suprachiasmatic nucleus (SCN). Last, we found a DMH neuron subpopulation that projects to the SCN with the capacity to influence the phase of the circadian clock. This direct DMH-SCN connection is well situated to integrate the metabolic and circadian systems, facilitating mealtime anticipation.

摘要

明显的线索，如升起的太阳或食物的可获得性，使生物钟适应行为。食物可获得性的同步机制仍然难以捉摸。在预定的喂食过程中使用单细胞 RNA 测序，我们确定了一个表达瘦素受体的下丘脑背内侧（DMH）神经元群体，该群体在预期的餐前上调昼夜节律同步基因并表现出钙活性。外源性瘦素、DMH 神经元的沉默或化学遗传刺激会破坏分子和行为食物同步的发展。DMH 神经元的重复激活导致与刺激同步且依赖于完整的视交叉上核（SCN）的第二波昼夜节律性运动活动的分区。最后，我们发现了一个 DMH 神经元亚群，它投射到 SCN，具有影响生物钟相位的能力。这种直接的 DMH-SCN 连接非常适合整合代谢和昼夜节律系统，促进进餐时间的预期。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/09ed5ed9338c/sciadv.adh9570-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/ee125545cb81/sciadv.adh9570-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/7df49d4feae9/sciadv.adh9570-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/609b605cc36d/sciadv.adh9570-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/820913333740/sciadv.adh9570-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/68cf1645f399/sciadv.adh9570-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/dbbbb711c6a8/sciadv.adh9570-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/e0bdee8b1ec2/sciadv.adh9570-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/9cfc08d3317c/sciadv.adh9570-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/8eda35615058/sciadv.adh9570-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/09ed5ed9338c/sciadv.adh9570-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/ee125545cb81/sciadv.adh9570-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/7df49d4feae9/sciadv.adh9570-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/609b605cc36d/sciadv.adh9570-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/820913333740/sciadv.adh9570-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/68cf1645f399/sciadv.adh9570-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/dbbbb711c6a8/sciadv.adh9570-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/e0bdee8b1ec2/sciadv.adh9570-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/9cfc08d3317c/sciadv.adh9570-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/8eda35615058/sciadv.adh9570-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2311/10456850/09ed5ed9338c/sciadv.adh9570-f10.jpg

相似文献

1
Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network.腹内侧下丘脑的瘦素受体神经元输入到昼夜节律性摄食网络中。
Sci Adv. 2023 Aug 25;9(34):eadh9570. doi: 10.1126/sciadv.adh9570.
2
A leptin-responsive hypothalamic circuit inputs to the circadian feeding network.一条对瘦素敏感的下丘脑回路向昼夜节律进食网络输入信号。
bioRxiv. 2023 Feb 26:2023.02.24.529901. doi: 10.1101/2023.02.24.529901.
3
Leptin receptor neurons in the dorsomedial hypothalamus regulate diurnal patterns of feeding, locomotion, and metabolism.腹内侧下丘脑的瘦素受体神经元调节摄食、运动和代谢的昼夜节律模式。
Elife. 2021 Feb 2;10:e63671. doi: 10.7554/eLife.63671.
4
Interaction between hypothalamic dorsomedial nucleus and the suprachiasmatic nucleus determines intensity of food anticipatory behavior.下丘脑背内侧核与视交叉上核之间的相互作用决定了食物预期行为的强度。
Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5813-8. doi: 10.1073/pnas.1015551108. Epub 2011 Mar 14.
5
Leptin signaling in the dorsomedial hypothalamus couples breathing and metabolism in obesity.腹内侧下丘脑的瘦素信号传递将肥胖中的呼吸和代谢联系起来。
Cell Rep. 2023 Dec 26;42(12):113512. doi: 10.1016/j.celrep.2023.113512. Epub 2023 Nov 30.
6
The suprachiasmatic nucleus participates in food entrainment: a lesion study.视交叉上核参与摄食节律的调整：一项损毁研究。
Neuroscience. 2010 Feb 17;165(4):1115-26. doi: 10.1016/j.neuroscience.2009.11.061. Epub 2009 Dec 23.
7
Feeding Time Entrains the Olfactory Bulb Circadian Clock in Anosmic PER2::LUC Mice.嗅觉缺失的 PER2::LUC 小鼠的进食时间可驯化嗅球生物钟。
Neuroscience. 2018 Nov 21;393:175-184. doi: 10.1016/j.neuroscience.2018.10.009. Epub 2018 Oct 12.
8
TrkB-expressing neurons in the dorsomedial hypothalamus are necessary and sufficient to suppress homeostatic feeding.背内侧下丘脑表达 TrkB 的神经元是抑制稳态进食所必需且充分的。
Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3256-3261. doi: 10.1073/pnas.1815744116. Epub 2019 Feb 4.
9
Neurobiology of food anticipatory circadian rhythms.食物预期昼夜节律的神经生物学。
Physiol Behav. 2011 Sep 26;104(4):535-45. doi: 10.1016/j.physbeh.2011.04.015. Epub 2011 Apr 20.
10
Circadian rhythms of PERIOD1 expression in the dorsomedial hypothalamic nucleus in the absence of entrained food-anticipatory activity rhythms in rats.大鼠中背内侧下丘脑核中 PERIOD1 表达的昼夜节律，而不存在被食物预期活动节律驯化的情况。
Eur J Neurosci. 2009 Jun;29(11):2217-22. doi: 10.1111/j.1460-9568.2009.06766.x. Epub 2009 May 21.

引用本文的文献

1
A stress-sensing circuit signals to the central pacemaker to reprogram circadian rhythms.一个压力感应电路向中央起搏器发出信号，以重新设定昼夜节律。
Sci Adv. 2025 Jun 20;11(25):eadr7960. doi: 10.1126/sciadv.adr7960.
2
Medial hypothalamic MC3R signalling regulates energy rheostasis in adult mice.下丘脑内侧的MC3R信号通路调节成年小鼠的能量稳态。
J Physiol. 2025 Jan;603(2):379-410. doi: 10.1113/JP286699. Epub 2024 Dec 24.
3
Molecular connectomics reveals a glucagon-like peptide 1-sensitive neural circuit for satiety.分子连接组学揭示了一种对胰高血糖素样肽1敏感的饱腹感神经回路。

本文引用的文献

1
Cholecystokinin neurons in mouse suprachiasmatic nucleus regulate the robustness of circadian clock.小鼠视交叉上核中的胆囊收缩素神经元调节生物钟的稳健性。
Neuron. 2023 Jul 19;111(14):2201-2217.e4. doi: 10.1016/j.neuron.2023.04.016. Epub 2023 May 11.
2
Arginine-vasopressin-expressing neurons in the murine suprachiasmatic nucleus exhibit a circadian rhythm in network coherence in vivo.在活体小鼠视交叉上核中表达精氨酸加压素的神经元表现出网络相干性的昼夜节律。
Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2209329120. doi: 10.1073/pnas.2209329120. Epub 2023 Jan 19.
3
Studying food entrainment: Models, methods, and musings.
Nat Metab. 2024 Dec;6(12):2354-2373. doi: 10.1038/s42255-024-01168-8. Epub 2024 Dec 3.
4
A hypothalamic circuit for circadian regulation of corticosterone secretion.一条用于昼夜节律调节皮质酮分泌的下丘脑回路。
Res Sq. 2024 Jul 12:rs.3.rs-4718850. doi: 10.21203/rs.3.rs-4718850/v1.
5
Neuroanatomical dissection of the MC3R circuitry regulating energy rheostasis.调节能量稳态的黑皮质素受体3（MC3R）神经回路的神经解剖学剖析。
bioRxiv. 2024 Apr 26:2024.04.22.590573. doi: 10.1101/2024.04.22.590573.
6
Leptin signaling and its central role in energy homeostasis.瘦素信号传导及其在能量平衡中的核心作用。
Front Neurosci. 2023 Oct 31;17:1238528. doi: 10.3389/fnins.2023.1238528. eCollection 2023.
7
AgRP neurons encode circadian feeding time.AgRP 神经元编码昼夜节律性摄食时间。
Nat Neurosci. 2024 Jan;27(1):102-115. doi: 10.1038/s41593-023-01482-6. Epub 2023 Nov 13.
研究食物诱导：模型、方法与思考。
Front Nutr. 2022 Sep 21;9:998331. doi: 10.3389/fnut.2022.998331. eCollection 2022.
4
Fos ensembles encode and shape stable spatial maps in the hippocampus.Fos 集合在海马体中编码和塑造稳定的空间图谱。
Nature. 2022 Sep;609(7926):327-334. doi: 10.1038/s41586-022-05113-1. Epub 2022 Aug 24.
5
Dopamine systems and biological rhythms: Let's get a move on.多巴胺系统与生物节律：让我们行动起来。
Front Integr Neurosci. 2022 Jul 27;16:957193. doi: 10.3389/fnint.2022.957193. eCollection 2022.
6
A building block-based beam-break (B) locomotor activity monitoring system and its use in circadian biology research.基于积木的光束中断（B）运动活动监测系统及其在昼夜节律生物学研究中的应用。
Biotechniques. 2022 Aug;73(2):104-109. doi: 10.2144/btn-2022-0036. Epub 2022 Jul 18.
7
Multiple entrained oscillator model of food anticipatory circadian rhythms.多约束振荡器模型的食物预期昼夜节律。
Sci Rep. 2022 Jun 3;12(1):9306. doi: 10.1038/s41598-022-13242-w.
8
Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice.限时进食起始时间与生物钟同步可延长雄性 C57BL/6J 小鼠寿命。
Science. 2022 Jun 10;376(6598):1192-1202. doi: 10.1126/science.abk0297. Epub 2022 May 5.
9
Randomized controlled trial for time-restricted eating in healthy volunteers without obesity.限时进食对非肥胖健康志愿者的随机对照试验。
Nat Commun. 2022 Feb 22;13(1):1003. doi: 10.1038/s41467-022-28662-5.
10
Light sets the brain's daily clock by regional quickening and slowing of the molecular clockworks at dawn and dusk.光线通过黎明和黄昏时分分子钟的区域加速和减速来设定大脑的日常生物钟。
Elife. 2021 Dec 20;10:e70137. doi: 10.7554/eLife.70137.