Matsson P, Enander I, Andersson A S, Nystrand J, Schwartz L, Watkins J
Pharmacia Diagnostics AB, Uppsala, Sweden.
Agents Actions. 1991 May;33(1-2):218-20. doi: 10.1007/BF01993172.
Tryptase is predominantly found in mast cells, where it resides in secretory granules, and is released with other mediators during mast cell degranulation. By using a newly developed commercial assay for measurements of tryptase levels we have investigated two cases of suspected drug-induced anaphylaxis. Each patient had a similar clinical presentation, consisting of hypotension and cyanosis after administration of thiopentone and suxamethonium. One of the patients showed a highly elevated serum level of tryptase reaching 26 micrograms/l 30 min after the initial reaction. In addition, slightly elevated levels of specific IgE antibodies to thiopentone were detected. The other patient with similar symptoms showed no increase in the level of tryptase, nor any specific IgE to thiopentone or suxamethonium. These data indicate the patient I suffered from true anaphylaxis, whereas the reaction of patient II occurred by a different mechanism.
类胰蛋白酶主要存在于肥大细胞中，它存在于分泌颗粒中，并在肥大细胞脱颗粒过程中与其他介质一起释放。通过使用一种新开发的用于测量类胰蛋白酶水平的商业检测方法，我们研究了两例疑似药物性过敏反应的病例。每位患者都有相似的临床表现，包括在使用硫喷妥钠和琥珀酰胆碱后出现低血压和发绀。其中一名患者在初次反应后30分钟血清类胰蛋白酶水平大幅升高，达到26微克/升。此外，还检测到针对硫喷妥钠的特异性IgE抗体水平略有升高。另一名有类似症状的患者类胰蛋白酶水平没有升高，也没有针对硫喷妥钠或琥珀酰胆碱的特异性IgE。这些数据表明患者I患有真正的过敏反应，而患者II的反应是由不同机制引起的。
