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用于专用6兆伏放射外科直线加速器的中心轴剂量学数据的解析计算。

Analytical calculation of central-axis dosimetric data for a dedicated 6-MV radiosurgery linear accelerator.

作者信息

Yang James N, Pino Ramiro

机构信息

Department of Radiation Physics, Unit 94, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

出版信息

Med Phys. 2008 Oct;35(10):4333-41. doi: 10.1118/1.2975142.

Abstract

Narrow beams are extensively used in stereotactic radiosurgery. The accuracy of treatment planning dose calculation depends largely on how well the dosimetric data are measured during the machine commissioning. Narrow beams are characterized by the lack of lateral electronic equilibrium. The lateral electronic disequilibrium in the radiation field and detector's finite size are likely to compromise the accuracy in dose measurements in these beams. This may have a profound impact on outcome in patients who undergo stereotactic radiosurgery. To confirm the measured commissioning data for a dedicated 6-MV linear accelerator-based radiosurgery system, we developed an analytical model to calculate the narrow photon beam central-axis dose. This model is an extension of a previously reported method of Nizin and Mooij for the calculation of the absorbed dose under lateral electronic disequilibrium conditions at depth of dmax or greater. The scatter factor and tissue-maximum ratio were calculated for narrow beams using the parametrized model and compared to carefully measured results for the same beams. For narrow beam radii ranging from 0.2 to 1.5 cm, the differences between the analytical and measured scatter factors were no greater than 1.4%. In addition, the differences between the analytical and measured tissue-maximum ratios were within 3.3% for regions greater than the maximum dose depth. The estimated error of this analytical calculation was less than 2%, which is sufficient to validate measurement results.

摘要

窄束广泛应用于立体定向放射外科手术中。治疗计划剂量计算的准确性在很大程度上取决于在机器调试期间剂量学数据的测量精度。窄束的特点是缺乏横向电子平衡。辐射场中的横向电子不平衡和探测器的有限尺寸可能会影响这些束流中剂量测量的准确性。这可能会对接受立体定向放射外科手术的患者的治疗结果产生深远影响。为了验证基于专用6兆伏直线加速器的放射外科系统的测量调试数据,我们开发了一个分析模型来计算窄光子束中心轴剂量。该模型是对Nizin和Mooij先前报道的在dmax深度或更深处横向电子不平衡条件下计算吸收剂量方法的扩展。使用参数化模型计算窄束的散射因子和组织最大剂量比,并与相同束流的精确测量结果进行比较。对于半径范围为0.2至1.5厘米的窄束,分析散射因子与测量散射因子之间的差异不超过1.4%。此外,对于大于最大剂量深度的区域,分析组织最大剂量比与测量组织最大剂量比之间的差异在3.3%以内。这种分析计算的估计误差小于2%,足以验证测量结果。

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