Horenstein Marcelo G, Moontasri Nancy J, Cesarman Ethel
Department of Dermatopathology, The Dermatology Group, Verona, NJ 07044, USA.
J Cutan Pathol. 2008 Nov;35 Suppl 2:40-4. doi: 10.1111/j.1600-0560.2008.01118.x.
Since the perplexing early Kaposi's sarcoma (KS) observations at the dawn of the acquired immunodeficiency syndrome epidemic, KS has been extensively studied, revealing a complex disease. The identification and complete elucidation of the genome of its causal agent, the KS-associated herpesvirus/human herpesvirus 8, have shed important insights into the pathobiology of this disease. The purpose of this review is to describe the scientific advances and understanding of KS over the past three decades.
自获得性免疫缺陷综合征流行初期对卡波西肉瘤（KS）的令人困惑的早期观察以来，KS已得到广泛研究，揭示出这是一种复杂的疾病。其病原体——卡波西肉瘤相关疱疹病毒/人类疱疹病毒8——的基因组的鉴定和完整阐释，为该疾病的病理生物学提供了重要见解。本综述的目的是描述过去三十年里在KS研究方面取得的科学进展以及对KS的认识。
