Levita Liat, Hare Todd A, Voss Henning U, Glover Gary, Ballon Douglas J, Casey B J
Sackler Institute for Developmental Psychobiology, Institute of Psychiatry, Weill Cornell Medical College, New York, NY, USA.
Neuroimage. 2009 Feb 1;44(3):1178-87. doi: 10.1016/j.neuroimage.2008.09.039. Epub 2008 Oct 11.
An increasing body of evidence suggests that the nucleus accumbens (NAcc) is engaged in both incentive reward processes and in adaptive responses to conditioned and unconditioned aversive stimuli. Yet, it has been argued that NAcc activation to aversive stimuli may be a consequence of the rewarding effects of their termination, i.e., relief. To address this question we used fMRI to delineate brain response to the onset and offset of unpleasant and pleasant auditory stimuli in the absence of learning or motor response. Increased NAcc activity was seen for the onset of both pleasant and unpleasant stimuli. Our results support the expanded bivalent view of NAcc function and call for expansion of current models of NAcc function that are solely focused on reward.
越来越多的证据表明，伏隔核（NAcc）参与了激励奖励过程以及对条件性和非条件性厌恶刺激的适应性反应。然而，有人认为，NAcc对厌恶刺激的激活可能是其终止所带来的奖励效应的结果，即缓解。为了解决这个问题，我们使用功能磁共振成像（fMRI）来描绘在没有学习或运动反应的情况下，大脑对不愉快和愉快听觉刺激的开始和结束的反应。在愉快和不愉快刺激开始时，都观察到NAcc活动增加。我们的结果支持了关于NAcc功能的扩展二价观点，并呼吁扩展目前仅关注奖励的NAcc功能模型。
