GPR39是肥胖抑制素的天然受体吗？
Is GPR39 the natural receptor of obestatin?
作者信息
Dong Xiao-Ying, He Jin-Ming, Tang Sheng-Qiu, Li Hai-Yun, Jiang Qing-Yan, Zou Xiao-Ting
机构信息
College of Yingdong Bioengineering, Shaoguan University, Daxue Avenue, Zhenjiang District, Shaoguan 512005, China.
出版信息
Peptides. 2009 Feb;30(2):431-8. doi: 10.1016/j.peptides.2008.09.022. Epub 2008 Oct 10.
GPR39, an orphan receptor belonging to the family of G protein-coupled receptors, was originally reported to be the receptor of obestatin. However recently, numerous reports have questioned this conclusion. In mammals, GPR39 was reported to be involved in the regulation of gastrointestinal and the metabolic functions. In this article, a latest and brief review on the receptor family, structure, distribution and physiological functions of GPR39 has been reported.
GPR39是一种属于G蛋白偶联受体家族的孤儿受体，最初报道称它是肥胖抑制素的受体。然而，最近大量报告对这一结论提出了质疑。在哺乳动物中，据报道GPR39参与胃肠道和代谢功能的调节。本文对GPR39的受体家族、结构、分布和生理功能进行了最新的简要综述。
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