Hatakka Katja, Mutanen Marja, Holma Reetta, Saxelin Maija, Korpela Riitta
Department of Applied Chemistry and Microbiology, Nutrition, Institute of Biomedicine, Pharmacology, University of Helsinki, Finland.
J Am Coll Nutr. 2008 Aug;27(4):441-7. doi: 10.1080/07315724.2008.10719723.
The aim of this study was to examine the effect of the administration of Lactobacillus rhamnosus strain LC705 and Propionibacterium freudenreichii ssp shermanii strain JS in capsules on serum cholesterol and triglyceride levels in mildly or moderately hypercholesterolemic men.
Thirty-eight basically healthy men, mean age 42 years (range 24-55), mean cholesterol 6.2 mmol/L (5.3-8.2 mmol/L), participated in this double-blind, randomised, placebo-controlled, two-period crossover study with 4-week treatment periods. The subjects consumed daily two probiotic capsules containing viable Lactobacillus rhamnosus LC705 and Propionibacterium freudenreichii ssp shermanii JS (2 x 10(10) colony forming units of each strain daily) or two placebo capsules. Serum lipids were assessed before the intervention, at the end of both 4-week treatment periods, and 2 weeks after the second treatment period. Dietary and lifestyle habits were carefully monitored.
All the subjects completed the study, and the probiotic capsules were well tolerated. Dietary habits and the intake of energy and nutrients, such as saturated fatty acids and cholesterol, did not differ between the treatment groups. No changes in total cholesterol, HDL cholesterol, LDL cholesterol or triglyceride levels were observed during the consumption of the probiotics compared to placebo.
The administration of Lactobacillus rhamnosus LC705 and Propionibacterium freudenreichii ssp shermanii JS did not affect serum lipids.
本研究旨在探讨鼠李糖乳杆菌LC705菌株和谢氏丙酸杆菌JS菌株胶囊给药对轻度或中度高胆固醇血症男性血清胆固醇和甘油三酯水平的影响。
38名基本健康的男性，平均年龄42岁（范围24 - 55岁），平均胆固醇水平为6.2 mmol/L（5.3 - 8.2 mmol/L），参与了这项双盲、随机、安慰剂对照、两阶段交叉研究，治疗期为4周。受试者每天服用两粒含有活性鼠李糖乳杆菌LC705和谢氏丙酸杆菌JS的益生菌胶囊（每种菌株每日2×10¹⁰菌落形成单位）或两粒安慰剂胶囊。在干预前、两个4周治疗期结束时以及第二个治疗期结束后2周评估血清脂质。仔细监测饮食和生活方式习惯。
所有受试者均完成研究，益生菌胶囊耐受性良好。治疗组之间的饮食习惯以及能量和营养素（如饱和脂肪酸和胆固醇）的摄入量没有差异。与安慰剂相比，在服用益生菌期间未观察到总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇或甘油三酯水平的变化。
鼠李糖乳杆菌LC705和谢氏丙酸杆菌JS的给药对血清脂质无影响。
