Zhao Ya-shuang, Zhu Sui, Li Xiang-wei, Wang Fan, Hu Fu-lan, Li Dan-dan, Zhang Wen-cui, Li Xia
Department of Epidemiology, Harbin Medical University, Heilongjiang, People's Republic of China.
Breast Cancer Res Treat. 2009 Sep;117(1):141-50. doi: 10.1007/s10549-008-0228-6. Epub 2008 Nov 2.
The association between non-steroidal anti-inflammatory drugs (NSAIDs) use and breast cancer has remained controversial. Therefore, an overall quantitative estimate of the association needs to be studied. A systematic review and meta-analysis was executed to explore the pooled estimate for relative risk (RR) and 95% confidence interval (CI) using random or fixed effects models based on heterogeneity analysis. Overall 26 studies with 528,705 participants were included. The RR of NSAIDs use and the incidence of breast cancer was 0.94 (95% CI: 0.88-1.00) with random effects model. A slight reduction of breast cancer by taking aspirin and ibuprofen was both observed with pooled RR of 0.91 (95% CI: 0.83-0.98) and 0.81 (95% CI: 0.67-0.97), respectively. Our results indicate that NSAIDs use is associated with a slight decrease for the development of breast cancer with a marginally statistical significant difference. The associations are slightly more obvious in aspirin and ibuprofen use.
非甾体抗炎药（NSAIDs）的使用与乳腺癌之间的关联一直存在争议。因此，需要对这种关联进行全面的定量评估。我们进行了一项系统综述和荟萃分析，以基于异质性分析，使用随机或固定效应模型来探索相对风险（RR）和95%置信区间（CI）的合并估计值。总共纳入了26项研究，涉及528,705名参与者。采用随机效应模型时，NSAIDs使用与乳腺癌发病率的RR为0.94（95%CI：0.88 - 1.00）。服用阿司匹林和布洛芬分别使乳腺癌略有降低，合并RR分别为0.91（95%CI：0.83 - 0.98）和0.81（95%CI：0.67 - 0.97）。我们的结果表明，NSAIDs的使用与乳腺癌的发生略有降低相关，具有边缘统计学显著差异。在使用阿司匹林和布洛芬时，这种关联略显明显。
