Kaufmann Stefan H E
Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.
Scand J Infect Dis. 2008;40(8):595-600. doi: 10.1080/00365540802032759.
Vaccines are available for some, but not all, bacterial pathogens. Accordingly, bacterial pathogens still cause major health problems. Novel insights into the basic immunological mechanisms involved in protection against bacteria will provide guidelines for the design of novel vaccines. In particular, these include broad-acting vaccines composed of protein antigens shared by all members of a given pathogen group but absent in the human host and vaccines which operate via T-cells.
疫苗可用于预防某些但并非所有的细菌病原体。因此，细菌病原体仍然会引发重大的健康问题。对抵御细菌的基本免疫机制的新见解将为新型疫苗的设计提供指导。特别是，这些包括由特定病原体组所有成员共有的、但在人类宿主中不存在的蛋白质抗原组成的广谱疫苗，以及通过T细胞起作用的疫苗。
