Huygen K
Mycobacterial Immunology, Pasteur Institute, Brussels, Belgium.
Int J Tuberc Lung Dis. 1998 Dec;2(12):971-8.
Since the first observations in the early 1990s, the scientific literature on DNA vaccines has been growing exponentially. This article reviews the history and general principle, summarizes current knowledge on immune mechanisms, discusses safety considerations and highlights possible advantages of this technique as compared to the classic vaccines. Special emphasis is placed on the potential of DNA vaccines with respect to tuberculosis.
自20世纪90年代初首次观察以来，关于DNA疫苗的科学文献呈指数级增长。本文回顾了其历史和一般原理，总结了当前关于免疫机制的知识，讨论了安全性考量，并强调了该技术与传统疫苗相比可能具有的优势。特别强调了DNA疫苗在结核病方面的潜力。
