Motrescu Elena Roza, Rio Marie-Christine
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR 7104, INSERM U596, ULP, C.U. de Strasbourg, BP 10142, F-67404 Illkirch Cedex, France.
Biol Chem. 2008 Aug;389(8):1037-41. doi: 10.1515/BC.2008.110.
This brief review focuses on the emerging role of matrix metalloproteinase 11 (MMP-11) in cancer progression. It has recently been shown that MMP-11 is induced in adipose tissue by cancer cells as they invade their surrounding environment. MMP-11 negatively regulates adipogenesis by reducing pre-adipocyte differentiation and reversing mature adipocyte differentiation. Adipocyte dedifferentiation in turn leads to the accumulation of nonmalignant peritumoral fibroblast-like cells, which favor cancer cell survival and tumor progression. This MMP-11-mediated bi-directional cross-talk between invading cancer cells and adjacent adipocytes/pre-adipocytes highlights the central role that MMP-11 plays during tumor desmoplasia and represents a molecular link between obesity and cancer.
本简要综述聚焦于基质金属蛋白酶11（MMP - 11）在癌症进展中的新作用。最近研究表明，癌细胞在侵袭周围环境时会诱导脂肪组织中MMP - 11的产生。MMP - 11通过减少前脂肪细胞分化和逆转成熟脂肪细胞分化来负向调节脂肪生成。脂肪细胞去分化进而导致非恶性肿瘤周围成纤维细胞样细胞的积累，这有利于癌细胞存活和肿瘤进展。这种MMP - 11介导的侵袭性癌细胞与相邻脂肪细胞/前脂肪细胞之间的双向相互作用突出了MMP - 11在肿瘤促纤维增生过程中所起的核心作用，并代表了肥胖与癌症之间的分子联系。
