Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849, USA.
J Biomed Mater Res A. 2009 Nov;91(2):385-90. doi: 10.1002/jbm.a.32260.
An N-halamine precursor, 3-(5'-methyl-5'-hydantoinyl)acetanilide (I), was synthesized in our laboratory and loaded onto electrospun polyacrylonitrile fiber to prepare nanosized biocidal materials, which could be rendered antimicrobial by exposure to household bleach. Differential scanning calorimetry was used to study the thermal properties of the nanofibers with and without the N-halamine precursor and its chlorinated derivative loaded. Scanning electron microscopy demonstrated that the ultrafine fibers formed with diameters from 250 to 600 nm. Chlorinated nanofibrous mats composed of the fibers were challenged with Staphylococcus aureus (ATCC 6538) and Escherichia coli O157:H7 (ATCC 43895); they showed promising inactivation efficacies against the two bacterial species within 5 minutes of contact. Potential uses of the antimicrobial fibers include filters for industrial water and air disinfection and protective clothing.
一种 N-卤胺前体，3-(5'-甲基-5'-海因基)乙酰胺（I），由我们实验室合成，并负载到静电纺丝聚丙烯腈纤维上，制备纳米级的杀菌材料，通过暴露于家用漂白剂使其具有抗菌性。差示扫描量热法用于研究负载 N-卤胺前体及其氯化衍生物的纳米纤维的热性能。扫描电子显微镜表明，形成的超细纤维的直径从 250 到 600nm 不等。由这些纤维组成的氯化纤维毡与金黄色葡萄球菌（ATCC 6538）和大肠杆菌 O157:H7（ATCC 43895）进行了挑战；它们在接触 5 分钟内对两种细菌表现出有希望的灭活效果。抗菌纤维的潜在用途包括用于工业水和空气消毒的过滤器以及防护服。
