Ignatova Milena, Starbova Kirilka, Markova Nadya, Manolova Nevena, Rashkov Iliya
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Carbohydr Res. 2006 Sep 4;341(12):2098-107. doi: 10.1016/j.carres.2006.05.006. Epub 2006 Jun 5.
Nano-fibres containing quaternised chitosan (QCh) have been successfully prepared by electrospinning of QCh solutions mixed with poly(vinyl alcohol) (PVA). The average fibre diameter is in the range of 60-200 nm. UV irradiation of the composite electrospun nano-fibrous mats containing triethylene glycol diacrylate as cross-linking agent has resulted in stabilising of the nano-fibres against disintegration in water or water vapours. Microbiological screening has demonstrated the antibacterial activity of the photo-cross-linked electrospun mats against Staphylococcus aureus and Escherichia coli. The obtained nano-fibrous electrospun mats are promising for wound-healing applications.
通过静电纺丝含有季铵化壳聚糖（QCh）与聚乙烯醇（PVA）混合的溶液，成功制备了含季铵化壳聚糖的纳米纤维。平均纤维直径在60 - 200纳米范围内。对含有三甘醇二丙烯酸酯作为交联剂的复合静电纺纳米纤维垫进行紫外线照射，可使纳米纤维在水或水蒸气中保持稳定不分解。微生物筛选表明，光交联静电纺垫对金黄色葡萄球菌和大肠杆菌具有抗菌活性。所获得的纳米纤维静电纺垫在伤口愈合应用方面具有前景。
