含有腺苷酸激酶的智能水凝胶：将底物识别转化为宏观运动。
Smart hydrogels containing adenylate kinase: translating substrate recognition into macroscopic motion.
作者信息
Yuan Weiwei, Yang Jiyuan, Kopecková Pavla, Kopecek Jindrich
机构信息
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
出版信息
J Am Chem Soc. 2008 Nov 26;130(47):15760-1. doi: 10.1021/ja805634x.
Abstract
Enzyme-based hybrid hydrogels were prepared by covalently incorporating an adenylate kinase mutant, possessing two thiol groups, into HPMA copolymer- or PEG-based hydrogel structures. The nanoscale conformational change of enzyme, triggered by substrate recognition, translated into macroscopic motion of hydrogels.
摘要
通过将具有两个硫醇基团的腺苷酸激酶突变体共价掺入基于HPMA共聚物或聚乙二醇的水凝胶结构中，制备了基于酶的混合水凝胶。由底物识别引发的酶的纳米级构象变化转化为水凝胶的宏观运动。
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