Department of Chemistry, University of Basel, Mattenstrasse 24a, BPR-1096, 4058 Basel, Switzerland.
Molecules. 2020 Sep 7;25(18):4090. doi: 10.3390/molecules25184090.
Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompatibility, responsivity and displaying tunable chemical and mechanical properties. A complex scenario of molecular factors and conditions have to be taken into account to ensure the correct functionality of the bio-hydrogel as a scaffold or a delivery system, including the polymer backbone and biomolecule choice, polymerization conditions, architecture and biocompatibility. In this review, we present these key factors and conditions that have to match together to ensure the correct functionality of the bio-conjugated hydrogel. We then present recent examples of bio-conjugated hydrogel systems paving the way for regenerative medicine applications.
生物共轭水凝胶将合成网络的功能与生物分子的活性结合在一起，因此成为各种生物医学应用的一类有趣材料。这种组合允许对其功能和活性进行微调，同时保持生物相容性、响应性，并具有可调的化学和机械性能。为了确保生物水凝胶作为支架或输送系统的正确功能，需要考虑到分子因素和条件的复杂情况，包括聚合物主链和生物分子的选择、聚合条件、结构和生物相容性。在这篇综述中，我们介绍了这些关键因素和条件，它们必须相互匹配，以确保生物共轭水凝胶的正确功能。然后，我们介绍了生物共轭水凝胶系统的最新实例，为再生医学应用铺平了道路。
