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用于生物传感的开放式和封闭式微流体技术。

Open and closed microfluidics for biosensing.

作者信息

Ge Tianxin, Hu Wenxu, Zhang Zilong, He Xuexue, Wang Liqiu, Han Xing, Dai Zong

机构信息

Guangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instrument, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, No.66, Gongchang Road, Guangming District, Shenzhen, Guangdong, 518107, PR China.

Department of Mechanical Engineering, The Hong Kong Polytechnic University, 999077, Hong Kong, PR China.

出版信息

Mater Today Bio. 2024 Apr 4;26:101048. doi: 10.1016/j.mtbio.2024.101048. eCollection 2024 Jun.

DOI:10.1016/j.mtbio.2024.101048
PMID:38633866
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11022104/
Abstract

Biosensing is vital for many areas like disease diagnosis, infectious disease prevention, and point-of-care monitoring. Microfluidics has been evidenced to be a powerful tool for biosensing via integrating biological detection processes into a palm-size chip. Based on the chip structure, microfluidics has two subdivision types: open microfluidics and closed microfluidics, whose operation methods would be diverse. In this review, we summarize fundamentals, liquid control methods, and applications of open and closed microfluidics separately, point out the bottlenecks, and propose potential directions of microfluidics-based biosensing.

摘要

生物传感对于疾病诊断、传染病预防和即时护理监测等许多领域至关重要。通过将生物检测过程集成到手掌大小的芯片中，微流控技术已被证明是一种强大的生物传感工具。基于芯片结构，微流控技术有两种细分类型：开放式微流控和封闭式微流控，其操作方法各不相同。在本综述中，我们分别总结了开放式和封闭式微流控的基本原理、液体控制方法及应用，指出了瓶颈问题，并提出了基于微流控的生物传感的潜在发展方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/86702ff0448c/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/abc1c9bec343/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/57c11aeb42fc/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/7a0e80e74586/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/93f5655d7bcb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/5891f092a642/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/6d9bbe14c55b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/d703e4766023/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/26c2caab4485/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/0e5e5d525794/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/766c45093b92/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/86702ff0448c/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/abc1c9bec343/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/57c11aeb42fc/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/7a0e80e74586/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/93f5655d7bcb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/5891f092a642/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/6d9bbe14c55b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/d703e4766023/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/26c2caab4485/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/0e5e5d525794/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/766c45093b92/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aba/11022104/86702ff0448c/gr10.jpg

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3
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ACS Omega. 2025 Mar 25;10(13):12817-12836. doi: 10.1021/acsomega.4c10999. eCollection 2025 Apr 8.
基于光致马兰戈尼效应和不对称润湿脊的光敏含润滑剂光滑表面上的液滴传输
Soft Matter. 2023 Oct 4;19(38):7323-7333. doi: 10.1039/d3sm00887h.
4
Miniaturizing chemistry and biology using droplets in open systems.利用开放体系中的液滴实现化学和生物学的微型化。
Nat Rev Chem. 2023 Jun;7(6):439-455. doi: 10.1038/s41570-023-00483-0. Epub 2023 Apr 17.
5
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Nat Rev Chem. 2022 Jan;6(1):70-80. doi: 10.1038/s41570-021-00343-9. Epub 2021 Dec 13.
6
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Anal Chem. 2023 May 2;95(17):6905-6914. doi: 10.1021/acs.analchem.3c00150. Epub 2023 Apr 18.
7
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8
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9
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Influenza Other Respir Viruses. 2023 Mar 9;17(3):e13114. doi: 10.1111/irv.13114. eCollection 2023 Mar.