Schittenhelm Jens, Ebner Florian H, Tatagiba Marcos, Wolff Markus, Nägele Thomas, Meyermann Richard, Mittelbronn Michel
Institute of Brain Research, University of Tübingen, Calwerstr. 3, D-72076 Tübingen, Germany.
Clin Neurol Neurosurg. 2009 Feb;111(2):203-7. doi: 10.1016/j.clineuro.2008.09.014. Epub 2008 Nov 5.
Intramedullary glial neoplasms affecting the entire cord from the cervicomedullary junction to the conus are termed "holocord tumors" and those diagnosed as pilocytic astrocytoma are rare. Herein, we present a 13-year-old girl with a tumor extending from the cervicomedullary junction to the conus which was partially resected in a four-stage approach. Histopathological examination of all specimens resulted in diagnosis of a pilocytic astrocytoma. Although no signs of atypia were present, an elevated proliferative activity of endothelial vessels was noted. Residual parts of the tumor showed progress making additional surgery necessary. Therapy and its consequences are discussed and an overview of the literature of these rare longitudinally extensive intramedullary lesions is given.
累及从颈髓交界处到圆锥整个脊髓的髓内神经胶质肿瘤被称为“全脊髓肿瘤”，而诊断为毛细胞型星形细胞瘤的情况较为罕见。在此，我们报告一名13岁女孩，其肿瘤从颈髓交界处延伸至圆锥，采用四阶段方法进行了部分切除。对所有标本进行组织病理学检查后诊断为毛细胞型星形细胞瘤。尽管未发现异型性迹象，但注意到内皮血管的增殖活性升高。肿瘤残留部分出现进展，需要再次手术。讨论了治疗及其后果，并对这些罕见的纵向广泛髓内病变的文献进行了综述。
