Physiological Laboratory, University of Liverpool, Liverpool, UK.
Acta Physiol (Oxf). 2009 Jan;195(1):161-9. doi: 10.1111/j.1748-1716.2008.01931.x. Epub 2008 Oct 28.
Ca(2+) is one of the most ancient and ubiquitous second messengers. Highly polarized pancreatic acinar cells serve as an important cellular model for studies of Ca(2+) signalling and homeostasis. Downstream effects of Ca(2+) signalling have been and continue to be an important research avenue. The primary functions regulated by Ca(2+) in pancreatic acinar cells--exocytotic secretion and fluid secretion--have been defined and extensively characterized in the second part of the last century. The role of cytosolic Ca(2+) in cellular pathology and the related question of the interplay between Ca(2+) signalling and bioenergetics are important current research lines in our and other laboratories. Recent findings in these interwoven research areas are discussed in the current review.
钙离子是最古老和最普遍的第二信使之一。极化程度很高的胰腺腺泡细胞是研究钙离子信号转导和稳态的重要细胞模型。钙离子信号转导的下游效应一直是并且仍然是一个重要的研究方向。在上个世纪的后半叶，已经定义并广泛描述了钙离子在胰腺腺泡细胞中调节的主要功能——胞吐分泌和液体分泌。细胞溶质钙离子在细胞病理学中的作用以及钙离子信号转导和生物能量之间的相互作用相关问题是我们和其他实验室的当前重要研究方向。本综述讨论了这些相互交织的研究领域中的最新发现。
