Del Rosso James Q, Kim Grace
Valley Hospital Medical Center, 620 Shadow Lane, Las Vegas, NV 89106, USA.
Dermatol Clin. 2009 Jan;27(1):33-42. doi: 10.1016/j.det.2008.07.006.
Oral antibiotics are commonly used to treat acne vulgaris, primarily in patients presenting with moderate to severe facial or truncal disease severity. These agents are most appropriately used in combination with a topical regimen containing benzoyl peroxide and a topical retinoid. The most common oral antibiotics for treating acne vulgaris are the tetracycline derivatives, although macrolide agents such as erythromycin have also been used extensively. Over the past 4 decades, as the sensitivity of Propionibacterium acnes to several oral and topical antibiotics has decreased, the efficacy of oral tetracycline and erythromycin has markedly diminished, leading to increased use of doxycycline, minocycline, and other agents, such as trimethoprim/sulfamethoxazole.
口服抗生素常用于治疗寻常痤疮，主要用于面部或躯干疾病严重程度为中度至重度的患者。这些药物最适合与含有过氧化苯甲酰和外用维甲酸的局部治疗方案联合使用。治疗寻常痤疮最常用的口服抗生素是四环素衍生物，不过大环内酯类药物如红霉素也被广泛使用。在过去40年里，随着痤疮丙酸杆菌对几种口服和外用抗生素的敏感性下降，口服四环素和红霉素的疗效显著降低，导致强力霉素、米诺环素和其他药物（如甲氧苄啶/磺胺甲恶唑）的使用增加。
