Del Rosso James Q
Valley Hospital Medical Center, 620 Shadow Lane, Las Vegas, NV 89106, USA.
Dermatol Clin. 2009 Jan;27(1):91-4. doi: 10.1016/j.det.2008.07.011.
Oral antibiotics are commonly prescribed by dermatologists in clinical practice. When prescribing an oral antibiotic, as with other systemic medications, it is important to consider potential interactions with other drugs, including over-the-counter medications. The most common drug interaction mechanisms that may lead to clinically significant sequelae are inhibition of GI drug absorption and alterations in drug metabolism. Tetracycline and quinolones undergo chelation interactions with many metal ions found in antacids and mineral supplements. Some macrolides, such as erythromycin, inhibit the hepatic metabolism of many other drugs, increasing the risk for toxicity. Rifampin increases the metabolism of many other drugs, thus predisposing to treatment failure. Drug interactions can only be averted if their potential is understood and recognized in advance.
在临床实践中，皮肤科医生通常会开具口服抗生素。与其他全身用药一样，在开具口服抗生素时，必须考虑其与其他药物（包括非处方药）之间的潜在相互作用。可能导致具有临床意义的后遗症的最常见药物相互作用机制是抑制胃肠道药物吸收和改变药物代谢。四环素和喹诺酮类药物会与抗酸剂和矿物质补充剂中的许多金属离子发生螯合相互作用。一些大环内酯类药物，如红霉素，会抑制许多其他药物的肝脏代谢，增加毒性风险。利福平会加快许多其他药物的代谢，从而导致治疗失败。只有预先了解并认识到药物相互作用的可能性，才能避免它们的发生。
