Munckhof W J
Department of Infectious Diseases, Austin and Repatriation Medical Centre, Heidelberg, Victoria.
Aust Fam Physician. 1998 Oct;27(10):895-901.
Antibiotics are commonly prescribed to patients who are also taking other medications. Pharmacology textbooks contain long lists of potential interactions between antibiotics and other drugs, but only a few of these interactions have serious clinical consequences.
This review will highlight antibiotic interactions that are clinically significant, and the relative incidence and importance of each interaction will be considered. It will concentrate primarily on drugs commonly prescribed in general practice, such as the oral contraceptive pill and warfarin.
Quinolones and macrolides are the groups of antibiotics most commonly associated with clinically significant drug interactions. Warfarin interacts with many antibiotics, although the incidence of this interaction can range from predictable to rare. The association between most antibiotics and oral contraceptive failure is weak, with only sporadic case reports in the literature.
抗生素通常会开给正在服用其他药物的患者。药理学教科书列出了抗生素与其他药物之间大量潜在的相互作用，但其中只有少数相互作用会产生严重的临床后果。
本综述将重点介绍具有临床意义的抗生素相互作用，并考量每种相互作用的相对发生率和重要性。它将主要关注全科医疗中常用的药物，如口服避孕药和华法林。
喹诺酮类和大环内酯类是最常与具有临床意义的药物相互作用相关的抗生素类别。华法林与许多抗生素相互作用，尽管这种相互作用的发生率从可预测到罕见不等。大多数抗生素与口服避孕药失效之间的关联较弱，文献中仅有零星的病例报告。
