减少能量摄入：长寿健康生活的秘诀？
Reduced energy intake: the secret to a long and healthy life?
作者信息
Martin Bronwen, Golden Erin, Egan Josephine M, Mattson Mark P, Maudsley Stuart
机构信息
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore MD 21224.
出版信息
IBS J Sci. 2007 Sep;2(2):35-39.
Abstract
Reduced energy intake, or caloric restriction (CR), is known to extend life-span and to retard age-related health decline in a myriad of species, including nematode worms, flies, fish, mice and rats. The exact mechanism whereby CR exerts its life-extending and health-extending effects is unclear. CR however has been shown to improve insulin sensitivity, reduce oxidative stress and alter neuroendocrine responses and central nervous system (CNS) function in animals. In this review article we provide a comprehensive overview of the effects of CR on animal physiology and we discuss some of the potential molecular mechanisms and pathways whereby reduced energy intake can increase health-span and life-span. A better understanding of how energy intake can influence the aging process could lead to new strategies and therapeutics to reduce age-related decline and increase health-span.
摘要
已知能量摄入减少，即热量限制（CR），可延长多种物种的寿命，并延缓与年龄相关的健康衰退，这些物种包括线虫、果蝇、鱼类、小鼠和大鼠。CR发挥其延长寿命和促进健康作用的确切机制尚不清楚。然而，CR已被证明可改善动物的胰岛素敏感性、降低氧化应激，并改变神经内分泌反应和中枢神经系统（CNS）功能。在这篇综述文章中，我们全面概述了CR对动物生理学的影响，并讨论了一些潜在的分子机制和途径，通过这些机制和途径，能量摄入减少可增加健康寿命和寿命。更好地理解能量摄入如何影响衰老过程可能会带来新的策略和疗法，以减少与年龄相关的衰退并增加健康寿命。
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