Bauer Michael, Juckel Georg, Correll Christoph U, Leopold Karolina, Pfennig Andrea
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, Dresden, Germany.
Eur Arch Psychiatry Clin Neurosci. 2008 Nov;258 Suppl 5:50-4. doi: 10.1007/s00406-008-5009-z.
The combination of a long undetected illness and significant psychosocial impairment renders early identification and intervention a vital role in bipolar disorders. Early detection forms the basis for adequate education and for treatment from the beginning. Several lines of evidence indicate that the characterization of early phases in the development of bipolar disorders is feasible. Risk factors for the development of bipolar disorders have been established and a manic prodrome has been characterized that is sufficiently long to allow recognition and, potentially, intervention. Centers specifically focussing on early detection and prevention of bipolar disorders need to be established. More research in this field is warranted including both groups of symptomatic subjects and symptom-free persons, with and without a positive family history.
长期未被发现的疾病与严重的心理社会功能损害相结合，使得早期识别和干预在双相情感障碍中发挥着至关重要的作用。早期发现是进行充分教育和从一开始就进行治疗的基础。多条证据表明，双相情感障碍发展早期阶段的特征描述是可行的。双相情感障碍发展的危险因素已经明确，并且已经对躁狂前驱期进行了特征描述，其持续时间足够长，以便能够识别并有可能进行干预。需要建立专门致力于双相情感障碍早期发现和预防的中心。该领域需要更多的研究，包括有症状的受试者群体和无症状的人群，无论有无阳性家族史。
