Perse M, Cerar A, Injac R, Strukelj B
Institute of Pathology, University of Ljubljana, Korytkova 2, 1105, Ljubljana, Slovenia.
Pathol Oncol Res. 2009 Mar;15(1):115-21. doi: 10.1007/s12253-008-9117-x. Epub 2008 Nov 5.
Several animal models of breast cancer have been developed to study various aspects of breast cancer biology. Substantial evidence suggests that the N-methylnitrosourea (MNU) animal model mimics human breast cancer in many respects. It has therefore been used extensively to evaluate preventive and therapeutic agents for human breast cancer. Chemically induced rodent models are also suitable for studying malignant progression. Recently, Liska et al. [7] established two protocols of MNU administration depending on the animal's age and number of applications of carcinogen, with the aim of investigating the advanced stages of mammary gland tumours. We used the same protocol as Liska but have obtained substantially different results. These results are presented and discussed in the frame of suggested key drawbacks of the MNU induced breast cancer rat model, as a contribution to the debate about the suitability of that model for evaluating preventive and therapeutic agents.
为了研究乳腺癌生物学的各个方面，已经开发了几种乳腺癌动物模型。大量证据表明，N-甲基亚硝基脲（MNU）动物模型在许多方面模拟了人类乳腺癌。因此，它已被广泛用于评估人类乳腺癌的预防和治疗药物。化学诱导的啮齿动物模型也适用于研究恶性进展。最近，利什卡等人[7]根据动物年龄和致癌物应用次数建立了两种MNU给药方案，目的是研究乳腺肿瘤的晚期阶段。我们使用了与利什卡相同的方案，但得到了截然不同的结果。在MNU诱导的乳腺癌大鼠模型的关键缺点框架内展示并讨论了这些结果，作为对该模型评估预防和治疗药物适用性辩论的贡献。
