Demir Ismail, Nalçacioğlu Remziye, Gürel Nurten, Demirbağ Zihni
Karadeniz Teknik Universitesi, Biyoloji Bölümü, Trabzon, Turkey.
Turkiye Parazitol Derg. 2008;32(3):295-303.
Baculoviruses have become a noteworthy research and study material for various applications in recent years. They are used as insecticides in agriculture because of their high host specifity. Recombinant baculoviruses are being used in biotechnology for the expression of related genes under the control of strong polh and p10 genes promoters. They have attracted attention as gene therapy vectors in medicine. Baculoviruses can enter the mammalian cells; however, they neither replicate nor show any pathogenic effect. Also baculoviruses are model organisms for molecular biology studies of gene structure and organization. Although baculoviruses are used commonly, their genome replication is not understood. Most of the research data about this subject have been obtained during recent years. Human beings have just begun to benefit from the use of baculoviruses. Baculoviruses will serve science in the future as mentioned above. We believe that this review will contribute to the appreciation of the field in our country in regard to baculoviruses which are popular all over the world. For this reason, in this review after giving information about the biology of baculoviruses, replication of baculoviruses has been explained in detail.
近年来，杆状病毒已成为用于各种应用的重要研究材料。由于其宿主特异性高，它们在农业中用作杀虫剂。重组杆状病毒在生物技术中被用于在强多角体蛋白（polh）和p10基因启动子的控制下表达相关基因。它们作为医学中的基因治疗载体已引起关注。杆状病毒可以进入哺乳动物细胞；然而，它们既不复制也不表现出任何致病作用。此外，杆状病毒是用于基因结构和组织分子生物学研究的模式生物。尽管杆状病毒被广泛使用，但其基因组复制仍不清楚。关于这个主题的大多数研究数据是近年来获得的。人类刚刚开始从杆状病毒的使用中受益。如上所述，杆状病毒未来将为科学服务。我们相信，这篇综述将有助于我国对杆状病毒领域的认识，杆状病毒在世界各地都很受欢迎。因此，在这篇综述中，在介绍了杆状病毒的生物学特性后，详细解释了杆状病毒的复制。
