Tevosian Sergei G, Manuylov Nikolay L
Department of Genetics, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
Dev Dyn. 2008 Dec;237(12):3672-80. doi: 10.1002/dvdy.21784.
The mammalian embryonic gonad is a unique organ primordium in that it can adopt two different developmental fates-namely, differentiate as either a testis or an ovary-with dramatic consequences for an individual. While a molecular cascade culminating in testis development is well characterized, the ovarian pathways still remain enigmatic. The canonical Wnt/beta-catenin signaling implements a conserved mechanism of regulating gene expression that is integral to development of all metazoans. In this review, we summarize the recent evidence that suggests a central role for this signaling pathway in the development of the mammalian female.
哺乳动物的胚胎性腺是一种独特的器官原基，因为它可以有两种不同的发育命运——即分化为睾丸或卵巢——这对个体有重大影响。虽然导致睾丸发育的分子级联反应已得到充分表征，但卵巢发育途径仍然神秘莫测。经典的Wnt/β-连环蛋白信号传导实施了一种保守的基因表达调控机制，这对所有后生动物的发育都是不可或缺的。在这篇综述中，我们总结了最近的证据，这些证据表明该信号通路在哺乳动物雌性发育中起着核心作用。
