Ujhazy Eduard, Dubovicky Michal, Ponechalova Veronika, Navarova Jana, Brucknerova Ingrid, Snirc Vladimir, Mach Mojmir
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovakia.
Neuro Endocrinol Lett. 2008 Oct;29(5):639-43.
The 2-ethoxycarbonyl-8-methoxy-2,3,4,4a,5,9b-hexahydro-1H-pyrido-[4,3b] indolinium chloride (SMe1EC2) is a prospective antioxidant and neuroprotectant drug. The aim of the study was to evaluate the effect of SMe1EC2 on embryofetal development of rats.
The substance tested was administered orally to Wistar/DV rats from day 6 to day 15 of gestation at the doses 5, 50 and 250 mg/kg/day. The animals were killed on day 20 of gestation and uterine content was inspected. Live fetuses were examined for gross, skeletal and visceral anomalies.
Administration of SMe1EC2 did not induce any signs of maternal toxicity. No adverse effect of the substance tested was found on reproductive variables. Morphological examination of fetuses revealed no evidence of teratogenesis.
The prenatal toxicity study showed that the substance SMe1EC2 tested did not have embryotoxic and teratogenic effects on developing rats. Neither were any signs of maternal toxicity found.
2-乙氧羰基-8-甲氧基-2,3,4,4a,5,9b-六氢-1H-吡啶并[4,3b]吲哚氯化物（SMe1EC2）是一种有前景的抗氧化和神经保护药物。本研究的目的是评估SMe1EC2对大鼠胚胎发育的影响。
在妊娠第6天至第15天，将受试物质以5、50和250mg/kg/天的剂量口服给予Wistar/DV大鼠。在妊娠第20天处死动物并检查子宫内容物。对存活胎儿进行大体、骨骼和内脏异常检查。
给予SMe1EC2未引起任何母体毒性迹象。未发现受试物质对生殖变量有不良影响。对胎儿的形态学检查未发现致畸证据。
产前毒性研究表明，受试物质SMe1EC2对发育中的大鼠没有胚胎毒性和致畸作用。也未发现任何母体毒性迹象。
