Onik G, Cobb C, Cohen J, Zabkar J, Porterfield B
Department of Neurosurgery, Allegheny-Singer Research Institute, Pittsburgh, PA 15212-9986.
Radiology. 1988 Sep;168(3):629-31. doi: 10.1148/radiology.168.3.3043544.
Cryosurgery has previously been used successfully to treat prostatic carcinoma. Inability to monitor the freezing led to local complications that limited the use of this modality. In this animal study, monitoring of the freezing process was accomplished with real-time ultrasound. The margin of the frozen tissue appeared as a hyperechoic rim with posterior acoustic shadowing. The thawed cryolesions showed markedly decreased echogenicity compared with normal unfrozen prostate. These characteristic changes should allow safer and more efficacious application of prostatic cryosurgery.
冷冻手术此前已成功用于治疗前列腺癌。由于无法监测冷冻过程，导致出现局部并发症，限制了这种治疗方式的应用。在这项动物研究中，通过实时超声对冷冻过程进行了监测。冷冻组织的边缘呈现为高回声环，并伴有后方声影。与未冷冻的正常前列腺相比，解冻后的冷冻损伤显示回声明显降低。这些特征性变化应能使前列腺冷冻手术的应用更安全、更有效。
