一只母犬卵巢无性细胞瘤的免疫组织化学诊断

Immunohistochemistry diagnosis of an ovarian dysgerminoma in one bitch.

作者信息

Park J K, Goo M J, Hong I H, Ki M R, Han J Y, Jeong K S

机构信息

Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University, Daegu, Korea.

出版信息

Reprod Domest Anim. 2009 Oct;44(5):855-8. doi: 10.1111/j.1439-0531.2008.01135.x. Epub 2008 Nov 3.

DOI:10.1111/j.1439-0531.2008.01135.x

PMID:18992107

Abstract

An ovarian enlargement (diameter, 8 cm) was identified and surgically excised from a 5-year-old female dog. Microscopic examination of the multinodular neoplasm revealed sheets of polygonal neoplastic cells with large nuclei, frequent mitosis, necrosis and haemorrhage. Immunohistochemically, the neoplastic cells were positive for vimentin and alkaline phosphatase but were negative for CD3, CD79a, cytokeratin, alpha-fetoprotein, inhibin-alpha and S-100. The histopathological diagnosis of the mass was unilateral ovarian dysgerminoma.

摘要

从一只5岁雌性犬体内发现并手术切除了一个卵巢肿物（直径8厘米）。对这个多结节性肿瘤进行显微镜检查，发现有多片多边形肿瘤细胞，细胞核大，有频繁的有丝分裂、坏死和出血。免疫组织化学检测显示，肿瘤细胞波形蛋白和碱性磷酸酶呈阳性，但CD3、CD79a、细胞角蛋白、甲胎蛋白、抑制素α和S-100呈阴性。该肿物的组织病理学诊断为单侧卵巢无性细胞瘤。