Chandra A M, Woodard J C, Merritt A M
Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA.
Vet Pathol. 1998 Jul;35(4):308-11. doi: 10.1177/030098589803500412.
A yearling Arabian filly was referred to the Veterinary Medical Teaching Hospital with a history of weight loss, profound anemia, and peritoneal effusion. At necropsy, a large, soft, mottled tan and red neoplastic mass was at the pelvic inlet replacing the left ovary. Additional tumor nodules of various sizes were disseminated throughout the mesentery, diaphragm, and serosal surfaces of the abdominal viscera. Histologically, the neoplasm had sheets of large round to polygonal cells separated into lobules by fibrous connective tissue with multifocal areas of necrosis. Tumor cells stained strongly for alkaline phosphatase. Immunohistochemically, tumor cells expressed vimentin and were negative for cytokeratin. Ultrastructurally, the neoplastic cells had a characteristic nucleolus with an elaborate reticular nucleolonema in an irregular configuration. This is the first in-depth detailed report of this very rare germ cell tumor of the ovary in horses.
一匹一岁阿拉伯小母马被转诊至兽医教学医院，有体重减轻、严重贫血和腹腔积液病史。尸检时，在盆腔入口处有一个大的、柔软的、斑驳的棕褐色和红色肿瘤块，取代了左侧卵巢。大小不一的其他肿瘤结节散布于整个肠系膜、膈肌和腹腔脏器的浆膜表面。组织学上，肿瘤有大片大的圆形至多边形细胞，被纤维结缔组织分隔成小叶，并有多灶性坏死区域。肿瘤细胞碱性磷酸酶染色强阳性。免疫组化显示，肿瘤细胞表达波形蛋白，细胞角蛋白阴性。超微结构上，肿瘤细胞有一个特征性核仁，核仁丝呈不规则构型且结构精细。这是关于马卵巢这种非常罕见的生殖细胞肿瘤的首份深入详细报告。
