Strunk Anneliese, Imai Denise M, Osofsky Anna, Tell Lisa A
Research Boulevard Pet and Bird Hospital, 11679 Research Boulevard, Austin, TX 78757, USA.
Avian Dis. 2011 Mar;55(1):133-8. doi: 10.1637/9502-081510-Case.1.
This report describes a case of dysgerminoma in a 21-year-old eastern rosella (Platycercus eximius eximius) that presented with dyspnea and a severely distended coelom. The bird was euthanatized, and a large, left-sided coelomic mass was identified. Microscopically, the mass was composed of sheets and nests of round to polygonal neoplastic cells with lacy cytoplasm. The neoplastic cells were weakly positive for vimentin and c-kit but negative for pancytokeratin, AE1, and inhibin. On the basis of the histomorphology and immunoreactivity, the neoplasm was determined to be a dysgerminoma. The variability of histologic appearance and immunohistochemical staining of dysgerminomas in humans compared with veterinary species is discussed.
本报告描述了一只21岁的东部玫瑰鹦鹉(Platycercus eximius eximius)患无性细胞瘤的病例,该鹦鹉出现呼吸困难和体腔严重膨胀。对这只鸟实施了安乐死,发现左侧体腔有一个大肿块。显微镜下,肿块由圆形至多边形的肿瘤细胞片和巢组成,细胞质呈花边状。肿瘤细胞波形蛋白和c-kit弱阳性,但细胞角蛋白、AE1和抑制素阴性。根据组织形态学和免疫反应性,确定该肿瘤为无性细胞瘤。文中还讨论了人类与兽医物种中无性细胞瘤的组织学表现和免疫组化染色的变异性。