媒介蚊虫的分子遗传操纵
Molecular genetic manipulation of vector mosquitoes.
作者信息
Terenius Olle, Marinotti Osvaldo, Sieglaff Douglas, James Anthony A
机构信息
Department of Molecular Biology and Biochemistry, 3205 McGaugh Hall, University of California, Irvine, CA 92697, USA.
出版信息
Cell Host Microbe. 2008 Nov 13;4(5):417-23. doi: 10.1016/j.chom.2008.09.002.
Abstract
Genetic strategies for reducing populations of vector mosquitoes or replacing them with those that are not able to transmit pathogens benefit greatly from molecular tools that allow gene manipulation and transgenesis. Mosquito genome sequences and associated EST (expressed sequence tags) databases enable large-scale investigations to provide new insights into evolutionary, biochemical, genetic, metabolic, and physiological pathways. Additionally, comparative genomics reveals the bases for evolutionary mechanisms with particular focus on specific interactions between vectors and pathogens. We discuss how this information may be exploited for the optimization of transgenes that interfere with the propagation and development of pathogens in their mosquito hosts.
摘要
减少病媒蚊子种群数量或用无法传播病原体的蚊子取而代之的遗传策略，极大地受益于允许基因操作和转基因的分子工具。蚊子基因组序列和相关的EST（表达序列标签）数据库能够进行大规模研究，从而为进化、生化、遗传、代谢和生理途径提供新的见解。此外，比较基因组学揭示了进化机制的基础，特别关注病媒与病原体之间的特定相互作用。我们讨论了如何利用这些信息来优化干扰病原体在蚊子宿主中繁殖和发育的转基因。
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