基因与基因组：蚊子的进化与多样性。
Of Genes and Genomes: Mosquito Evolution and Diversity.
机构信息
Department of Ecology and Evolution, University of Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Department of Ecology and Evolution, University of Lausanne, 1015 Lausanne, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
出版信息
Trends Parasitol. 2019 Jan;35(1):32-51. doi: 10.1016/j.pt.2018.10.003. Epub 2018 Nov 1.
Mosquitoes are widely despised for their exasperating buzzing and irritating bites, and more poignantly because, during blood-feeding, females may transmit pathogens that cause devastating diseases. However, the ability to transmit such viruses, filarial worms, or malaria parasites varies greatly amongst the ∼3500 recognised mosquito species. Applying omics technologies to sample this diversity and explore the biology underlying these variations is bringing increasingly greater resolution that enhances our understanding of mosquito evolution. Here we review the current status of mosquito omics, or 'mozomics', resources and recent advances in their applications to characterise mosquito biology and evolution, with a focus on the intersection of evolutionary and functional genomics to understand the putative links between gene and genome dynamism and mosquito diversity.
蚊子因其恼人的嗡嗡声和令人讨厌的叮咬而广遭唾弃，更糟糕的是，在吸血过程中，雌性蚊子可能会传播病原体，从而导致毁灭性的疾病。然而，在约 3500 种已知的蚊子种类中，传播此类病毒、丝虫或疟原虫寄生虫的能力差异很大。应用组学技术来对这种多样性进行采样，并探索导致这些变化的生物学基础，正在为我们增强对蚊子进化的理解带来越来越高的分辨率。在这里，我们回顾了蚊子组学或“moszomics”资源的现状，以及它们在描述蚊子生物学和进化方面的最新进展，重点关注进化和功能基因组学的交叉点，以了解基因和基因组动态性与蚊子多样性之间的潜在联系。
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