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NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.淋病奈瑟菌。一、与克隆变异基因连锁的毒力。
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Clonal population structure of Neisseria meningitidis serogroup A isolated from epidemics and pandemics between 1915 and 1983.1915年至1983年间从流行性和大流行性疫情中分离出的A群脑膜炎奈瑟菌的克隆群体结构。
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Meningococcal disease in Ontario during the winter of 1988-1989.
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Clonal and variable properties of Neisseria meningitidis isolated from cases and carriers during and after an epidemic in The Gambia, West Africa.从西非冈比亚一次流行期间及之后的病例和携带者中分离出的脑膜炎奈瑟菌的克隆和可变特性。
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出现了一种2a血清型脑膜炎奈瑟菌的强毒株，该毒株与加拿大的C群脑膜炎球菌病有关。

Emergence of a virulent clone of Neisseria meningitidis serotype 2a that is associated with meningococcal group C disease in Canada.

作者信息

Ashton F E, Ryan J A, Borczyk A, Caugant D A, Mancino L, Huang D

机构信息

National Laboratory for Bacteriology, Laboratory Centre for Disease Control, Health and Welfare, Canada, Ottawa.

出版信息

J Clin Microbiol. 1991 Nov;29(11):2489-93. doi: 10.1128/jcm.29.11.2489-2493.1991.

DOI:10.1128/jcm.29.11.2489-2493.1991
PMID:1774254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC270360/
Abstract

Multilocus enzyme electrophoresis was used to characterize 378 isolates of Neisseria meningitidis serogroup C recovered during a period of an increase in group C meningococcal disease in Canada. Thirty-four enzyme electrophoretic types were found among the isolates, which were predominantly (96.0%) serotype 2a. One clone (ET 15), characterized by a rarely occurring allele for the enzyme fumarase, was responsible for a focal outbreak in Ontario followed by the spread of group C disease across the province. This clone, which occurred infrequently among strains isolated in 1986, accounted for over 65% of group C strains associated with meningococcal disease in Canada in 1990.

摘要

多位点酶电泳被用于鉴定在加拿大C群脑膜炎球菌病发病增加期间分离出的378株C群脑膜炎奈瑟菌。在这些分离株中发现了34种酶电泳类型，其中主要（96.0%）为血清型2a。一个克隆（ET 15），其特征是延胡索酸酶的等位基因罕见，导致了安大略省的局部暴发，随后C群疾病在全省传播。这个克隆在1986年分离的菌株中很少出现，在1990年加拿大与脑膜炎球菌病相关的C群菌株中占比超过65%。