干扰素调控基因数据库：INTERFEROME
INTERFEROME: the database of interferon regulated genes.
作者信息
Samarajiwa Shamith A, Forster Sam, Auchettl Katie, Hertzog Paul J
机构信息
Center for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia.
出版信息
Nucleic Acids Res. 2009 Jan;37(Database issue):D852-7. doi: 10.1093/nar/gkn732. Epub 2008 Nov 7.
INTERFEROME is an open access database of types I, II and III Interferon regulated genes (http://www.interferome.org) collected from analysing expression data sets of cells treated with IFNs. This database of interferon regulated genes integrates information from high-throughput experiments with annotation, ontology, orthologue sequences from 37 species, tissue expression patterns and gene regulatory information to enable a detailed investigation of the molecular mechanisms underlying IFN biology. INTERFEROME fulfils a need in infection, immunity, development and cancer research by providing computational tools to assist in identifying interferon signatures in gene lists generated by high-throughput expression technologies, and their potential molecular and biological consequences.
INTERFEROME是一个开放获取的数据库，收录了通过分析用干扰素（IFN）处理的细胞的表达数据集而得到的I型、II型和III型干扰素调节基因（http://www.interferome.org）。这个干扰素调节基因数据库将高通量实验信息与注释、本体论、来自37个物种的直系同源序列、组织表达模式和基因调控信息整合在一起，以便详细研究IFN生物学背后的分子机制。INTERFEROME通过提供计算工具来满足感染、免疫、发育和癌症研究的需求，这些工具有助于在高通量表达技术生成的基因列表中识别干扰素特征及其潜在的分子和生物学后果。
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