化脓性链球菌CovRS在铁饥饿和存在人阳离子抗菌肽LL-37的情况下介导生长。
Streptococcus pyogenes CovRS mediates growth in iron starvation and in the presence of the human cationic antimicrobial peptide LL-37.
作者信息
Froehlich Barbara J, Bates Christopher, Scott June R
机构信息
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
出版信息
J Bacteriol. 2009 Jan;191(2):673-7. doi: 10.1128/JB.01256-08. Epub 2008 Nov 7.
Abstract
We found that the global regulatory two-component signal transduction system CovRS mediates the ability of group A streptococcus (GAS) to grow under two stresses encountered during infection: iron starvation and the presence of LL-37. We also showed that CovRS regulates transcription of the multimetal transporter operon that is important for GAS growth in a low concentration of iron.
摘要
我们发现，全局调控双组分信号转导系统CovRS介导A组链球菌（GAS）在感染过程中遇到的两种应激条件下生长的能力：铁饥饿和LL-37的存在。我们还表明，CovRS调节多金属转运蛋白操纵子的转录，该操纵子对低铁浓度下GAS的生长很重要。
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