Yamauchi Satoshi, Masuda Toshiya, Sugahara Takuya, Kawaguchi Yuya, Ohuchi Maya, Someya Tatsushi, Akiyama Jun, Tominaga Shiori, Yamawaki Manami, Kishida Taro, Akiyama Koichi, Maruyama Masafumi
Faculty of Agriculture, Ehime University, Japan.
Biosci Biotechnol Biochem. 2008 Nov;72(11):2981-6. doi: 10.1271/bbb.80461. Epub 2008 Nov 7.
The antioxidant activity of butane-type lignans was evaluated. Secoisolariciresinol (SECO) and dihydroguaiaretic acid (DGA) showed higher radical scavenging activity than that of 7,7'-dioxodihydroguaiaretic acid (ODGA). SECO and DGA inhibited the oxidation of unsaturated fatty acid. Both enantiomers of DGA were also lipoxygenase inhibitors, but neither enantiomer of SECO inhibited the lipoxygenase activity.
评估了丁烷型木脂素的抗氧化活性。开环异落叶松脂素（SECO）和二氢愈创木酸（DGA）表现出比7,7'-二氧代二氢愈创木酸（ODGA）更高的自由基清除活性。SECO和DGA抑制不饱和脂肪酸的氧化。DGA的两种对映体也是脂氧合酶抑制剂，但SECO的两种对映体均未抑制脂氧合酶活性。
