Kawaguchi Yuya, Yamauchi Satoshi, Masuda Kenta, Nishiwaki Hisashi, Akiyama Koichi, Maruyama Masafumi, Sugahara Takuya, Kishida Taro, Koba Yojiro
Faculty of Agriculture, Ehime University, Japan.
Biosci Biotechnol Biochem. 2009 Aug;73(8):1806-10. doi: 10.1271/bbb.90167. Epub 2009 Aug 7.
The relationship between the stereochemistry and antimicrobial activity of butane-type lignans was clarified. All stereoisomers of dihydroguaiaretic acid (DGA) showed both antibacterial and antifungal activity. The (+)- and (-)-7,7'-dioxodihydroguaiaretic acid (ODGA) also showed both antibacterial and antifungal activity, while meso-ODGA did not show antibacterial activity, but showed antifungal activity. No activity of any stereoisomer of secoisolariciresinol (SECO) was apparent.
阐明了丁烷型木脂素的立体化学与抗菌活性之间的关系。二氢愈创木酸（DGA）的所有立体异构体均表现出抗菌和抗真菌活性。（+）-和（-）-7,7'-二氧代二氢愈创木酸（ODGA）也表现出抗菌和抗真菌活性，而内消旋ODGA没有抗菌活性，但具有抗真菌活性。开环异落叶松脂素（SECO）的任何立体异构体均未表现出明显活性。
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