Park Sunmin, Ahn Il Sung, Kwon Dae Young, Ko Byoung Seob, Jun Won Kyung
Department of Food and Nutrition, Institutes of Basic Science, Hoseo University, South Korea.
Biosci Biotechnol Biochem. 2008 Nov;72(11):2815-23. doi: 10.1271/bbb.80205. Epub 2008 Nov 7.
Ginseng root is known to induce anti-diabetic activity, but the key components involved are unknown. We investigated which major ginsenosides in ginseng enhanced glucose homeostasis by in vitro studies. Rb1 and Rg1 reduced the triglyceride accumulation in 3T3-L1 adipocytes by activating PKA with increased intracellular cAMP. However, the insulin-stimulated glucose uptake was enhanced by Rb1 and Rg1 via activation of phosphatidylinositol-3 kinase. Rb1 and Rg1 promoted glucose-stimulated insulin secretion and cell viability in Min6 cells through PKA which augmented IRS2 expression to enhance insulin/IGF-1 signaling. These results suggest that Rb1 and Rg1 improved glucose homeostasis through the activation of a PKA like glucagon-like peptide-1 receptor agonist.
人参根已知具有抗糖尿病活性，但其涉及的关键成分尚不清楚。我们通过体外研究调查了人参中的哪些主要人参皂苷可增强葡萄糖稳态。Rb1和Rg1通过激活PKA并增加细胞内cAMP来减少3T3-L1脂肪细胞中的甘油三酯积累。然而，Rb1和Rg1通过激活磷脂酰肌醇-3激酶来增强胰岛素刺激的葡萄糖摄取。Rb1和Rg1通过PKA促进Min6细胞中葡萄糖刺激的胰岛素分泌和细胞活力，PKA增强IRS2表达以增强胰岛素/IGF-1信号传导。这些结果表明，Rb1和Rg1通过激活类似胰高血糖素样肽-1受体激动剂的PKA改善了葡萄糖稳态。
